Ambrose began in the late 50s under a different name, they changed their name to "Ambrose" in the year 1960. Ambrose started in the year 1960 in the pilsen neighborhood. Upon the start up of Ambrose they soon ended up going to war with the ROYAL KINGS that also operated and started up in the Pilsen neighborhood. Eventually Ambrose was fighting with the Latin Counts in the 1960s another mexican gang just like Ambrose. Mexican immigration became a very large thing in the 1950s and 1960s and they soon started their own gangs to battle off racist white gangs in the area then they would eventually start fighting each other. Royal Kings and Ambrose fought during the 60s till Royal Kings went extinct. Ambrose has been a very slow growing organization in history, they were stricktly located in Pilsen for many years until they spread to South Chicago in about the later 80s to the 90s, and they also moved into Chicago Land suburbs and even other states such as Texas. By the early 1980s Ambrose had a presence on 26th and Kolin; 18th to 22nd/Ashland to Throop. They attended school at that time at Juarez H.S., Curie H.S., Farragut H.S., and Cooper Grade school. In 1980 Ambrose joined the Folks alliance this created a relationship with neighboring Folks gangs like: Satan Disciples, Gangsters Disciples, Racine Boys, and 26s. They battled with people nation gangs at that time right within their vicinity: Latin Counts, Kool Gang, Villa Lobos, Latin Kings, and Bishops. Ambrose did of course have other allies and enemies. Ambrose began to grow more in numbers later in the 80s into the 90s.
They soon were bringing in lots of money from drug sales. Ambrose developed a very close relationship with the Two Two Boys that still exists today, they even wear the same colors Black and Baby Blue (except for the 22 boys on 22nd and California who wear the original colors and Brown and Beige). Starting in the year 1991 the Ambrose began to engage in a large scale of interalliance wars with other Folks. The entire Folk nation was experiencing a high volume of interalliance wars in 1991. Ambrose soon was at war with pilsen gangs like SDs, Laraza, Party People, Two Six and others. According to members of Two Two boys Ambrose and Two Two Boys went to war with Two Six because some Two Sixs crashed an Ambrose and Two Two Boy party and shot up members of Ambrose and Two Two Boys.
In 1999 a Ambrose fatally shot a undercover Police officer in the head in the Pilsen neighborhood. The Amrose said that he thought the officer was a La Raza gang member which is a rival folk nation gang to Ambrose. After the shooting the Police launched operation "Blue Water" that targeted Ambrose gang members and their drug business. Over two years Police shut down PCP labs and arrested dozens of Ambrose. Major operations were shut down in Gary, Indiana when a lab was raided and PCP and guns were found. There was also a big bust on 71st and State. Police found out about the business through wire taps. Operation "Blue Water" seriously injured Ambrose operations. .